The One Protein That Prevents Brain Aging

Today we know Klotho, an enzyme in our brain that protects us from conditions related to aging. But what does this protein have that is so powerful to relativize the passage of time?

Experts and researchers of brain conditions related to aging know that if you have this enzyme in good quantities, that person will have a long and healthy life.

But why is having so much of the Klotho protein so positive for the human body? What is the cause and effect of this situation? Let’s try to find the answer.

The utilities and benefits of the enzyme Klotho

This enzyme accumulates in vascular structures in the brain called choroid plexuses. These cell clusters form the cerebrospinal fluid that creates the barrier that protects the blood’s central nervous system.

And now, according to a new study published in the journal PNAS by specialists at the Gladstone Institute, we know why this protein accumulates in these brain plexuses and not in other parts of the brain.

The reason for Klotho’s usefulness is that it powerfully reduces the level of brain inflammation, usually related to the cognitive impairment that accompanies old age and aging.

According to the study carried out among mice, it has been observed that the plexuses fall with age due to the lowering of the levels of this protein. This fall is associated with the growth of brain inflammation.

This phenomenon affects other regions of the brain, so when a small amount of this enzyme appears, the immune system is weakened, so that the cells involved in the immune response, like inflammatory molecules, access the site and cause changes that are related to the deterioration of cognitive functions.

These molecular changes contribute to the loss of cognition in the elderly through inflammation, which is why many elderly people suffer a decrease in their intellectual functions and show a greater tendency to suffer diseases related to infections, such as pneumonia.

According to the study, this situation is more clearly observed in patients with Alzheimer’s disease, since this ailment is totally related to brain inflammation, which is key in triggering it.

Now, the research team is preparing new tests to check whether the increase in Klotho production can contribute to delaying the appearance of inflammation and the decrease in intellectual faculties associated with old age.